PhD / Research Assistant - Department of Pediatrics
PhD Position / Research Assistant - Department of Pediatrics
PhD Position / Research Assistant - Department of Pediatrics
Universitätsklinikum Frankfurt, Frankfurt am Main
Knowledge becomes health - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 7,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital. PhD Position / Research Assistant - Department of Pediatrics (We are targeting applicants of all genders) Full time | limited | Announcement number: 442-2023 We are seeking a motivated PhD student/research assistant to join our team at Department of Pediatrics, starting from the earliest possible date. The laboratory is part of the Department of Pediatrics, the biggest children& s hospital in the Rhein-Main area. The position is established into the Leukemia Research Group (
) under management of Dr. Marit Vermunt, who recently started her research group within the department of pediatrics headed by Professor Dr. med. Jan-Henning Klusmann. The group works on cancer genomics and translational studies in carcinogenesis, with special focus on acute myeloid leukemia in children. Your role: You will define aberrant epigenetic programs that drive leukemia progression. You will study the role of CTCF in cancer. CTCF is a transcription factor with a multitude of functions within the (epi)genome. The focus will be on transcriptional regulation and genome architecture. You will identify genes and regulatory sites of interest with a potential role in leukemia via high throughput screening platforms (CRISPR-Cas9 and drug libraries) and validate them using cellular assays in primary murine and human cells as well as patient samples. The aim is to derive and evaluate therapeutic interventions to overcome current obstacles in the treatment of AML using our biobank of patient derived xenografts. These collaborative efforts will promote research on the therapeutic potential of targeting aberrant epigenetic networks in AML, with projected benefits for patients. You will drive a project that is at the interface of basic molecular biology and translational research. You will perform genome-wide analyses as well as in depth mechanistic studies. Who you are: You are a PhD candidate with a master in natural sciences. You should have a strong background in biology and genetics. Experience with bioinformatics will be considered a plus. Many of the techniques that will be used result in big data sets and so analysis of next generation sequencing data will be a large part of this PhD project. Knowledge of tissue culture and molecular biology are required. A FELASA certificate (or equivalent) is preferred. You should be highly motivated, able to work in a team, have good communication skills and be fluent in English (spoken and written). Due to legal regulations , a valid proof of measles immunity / measles vaccination is required. What we offer: Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes Work environment: You will work in a multidisciplinary team of basic and clinician scientists from the Department of Pediatrics. Mobility: Free public transport in all Hessen (Free State Ticket Hessen) Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (more information can be found here ), child care during holidays Health Promotion : Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise. Professional development: Internal and external training for your professional development Disabled applicants are preferred if they have the same personal and professional qualifications. Join our Team! Use the time until May 31, 2023 to apply. Please state the announcement number, a possible starting time and your salary expectations. For further information, please contact Professor Dr. med. Jan-Henning Klusmann (069 / 6301 - 85573). Apply now Universitätsklinikum Frankfurt | Recruiting Team | Theodor-Stern-Kai 7 | 60590 Frankfurt am Main | Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button »Online bewerben« ein. Rückfragen können Sie gerne an bewerbung& kgu.de richten. Bitte beachten Sie, dass keine Unterlagen zurückgeschickt werden. | Folgen Sie uns auf Instagram ( & ukf_karriere ); XING , LinkedIn .
PhD Position / Research Assistant - Department of Pediatrics
Universitätsklinikum Frankfurt60590 Sérifontaine
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